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Detection of Brodifacoum and other Rodenticides in Drug Mixtures using Thermal Desorption Direct Analysis in Real Time Mass Spectrometry ( TD ‐ DART ‐ MS )
Author(s) -
Robinson Elizabeth L.,
Sisco Edward
Publication year - 2019
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.13978
Subject(s) - dart ion source , drug detection , designer drug , synthetic cannabinoids , drugs of abuse , brodifacoum , thermal desorption , mass spectrometry , drug , illicit drug , chemistry , toxicology , chromatography , pharmacology , medicine , biology , desorption , rodenticide , organic chemistry , ion , biochemistry , cannabinoid , receptor , electron ionization , ionization , adsorption
In recent months, there has been increased reporting of seized drug and toxicology cases containing rodenticides, the active ingredient in rat poisons. Seeing as rodenticides are not scheduled substances, they are not commonly screened for in seized drug analysis. This work investigates the use of TD ‐ DART ‐ MS for the simultaneous detection of rodenticides and drugs. Six rodenticides were evaluated, an optimal method was established, and limits of detection in the tens of nanograms were calculated. Additional studies highlight that detection at less than 1% by weight in mixtures with AB ‐ FUBINACA , cocaine, heroin, or methamphetamine was possible. This work presents an optimized method for detection of these compounds, allowing for the simultaneous detection of drugs and rodenticides, providing drug chemists with a tool for rapid identification of these compounds for forensic or public health purposes.