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The Pharmacokinetics of Morphine and Codeine in Human Plasma and Urine after Oral Administration of Qiangli Pipa Syrup
Author(s) -
Guo Binbin,
Zhang Yuqiao,
Wang Shengfeng,
Ding Jinsong,
Zhou Wenhu
Publication year - 2018
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.13696
Subject(s) - codeine , morphine , pharmacology , pharmacokinetics , urine , dose , medicine , oral administration , opiate , drug , receptor
Abstract Papaveris pericarpium , a natural source of morphine and codeine, is the principal active component in many antitussive traditional Chinese medicines. We herein report the first PK study of papaveris pericarpium in human plasma and urine following oral administration of single (15, 30, 60 mL) and multiple dose (15 mL) of Qiangli Pipa Syrup (MOR 0.1 mg/mL, COD 0.028 mg/mL) by monitoring morphine and codeine using a HPLC‐MS/MS method. Their T max and t 1/2 values are independent of dosages, while the AUC 0− t linearly increased with higher dosages, indicating linear PK characteristics. AUC 0− t increased obviously after multiple doses, indicating possible risk of accumulative toxicity. Urine studies suggested risks of positive opiate drug tests with a cutoff of 300 ng/mL, which lasted 6–14 h at different doses. These results provide important information for clinical safety, efficacy and rational drug use of Qiangli Pipa Syrup and also guide the related judicial expertise of its administration.