Premium
Experimental Study on the Postmortem Redistribution of the Substituted Phenethylamine, 25B‐NBOMe
Author(s) -
ShintaniIshida Kaori,
Saka Kanju,
Nakamura Mami,
Yoshida Kenichi,
Ikegaya Hiroshi
Publication year - 2018
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.13583
Subject(s) - autopsy , phenethylamine , medicine , pharmacology , anesthesia , pathology
2‐(4‐Bromo‐2,5‐dimethoxyphenyl)‐N‐(2‐methoxybenzyl)ethanamine (25B‐ NBOM e) is a substituted phenethylamine, which has become highly prevalent worldwide since 2014. Recently, in an autopsy case involving fatal 25B‐ NBOM e intoxication, we found the postmortem increase of 25B‐ NBOM e concentration in the cardiac blood approximately 2 days after death. The aim of this study was to investigate the distribution of 25B‐ NBOM e and reproduce the postmortem redistribution using a rat model. Sprague‐Dawley rats were killed 30 min after intraperitoneal injection of 25B‐ NBOM e (0.5 mg/kg) and left for 0, 3, 6, 9, 15, or 24 h (six rats at each time point). Postmortem 25B‐ NBOM e concentrations in the cardiac blood increased by more than 10‐fold at 6‐h postmortem. 25B‐ NBOM e accumulated primarily in the lung. Moreover, this postmortem redistribution occurred even in rats that had died 1 week following the 25B‐ NBOM e administration. These findings indicate that attention should be paid to sample collection and data interpretation in the toxicological analysis of 25B‐ NBOM e.