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Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
Author(s) -
CarvajalZarrabal Octavio,
HaywardJones Patricia M.,
NolascoHipolito Cirilo,
BarradasDermitz Dulce Ma.,
CalderónGarcidueñas Ana Laura,
LópezAmador Noé
Publication year - 2017
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.13397
Subject(s) - forensic pathology , medicine , creatine kinase , troponin , sudden cardiac death , myoglobin , troponin t , lactate dehydrogenase , cardiology , cardiac enzymes , cause of death , autopsy , pathology , disease , biology , myocardial infarction , enzyme , biochemistry
In the daily practice of forensic pathology, sudden cardiac death ( SCD ) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK ‐ MB , myoglobin, troponins I and T ( cT n‐I and T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD . Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means ( p < 0.05). SCD cases showed significantly higher levels ( p < 0.05) of cT n‐T and cT n‐I compared to the control group. Although only cases within the first 8 h of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.
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