Premium
Development of a Library Search‐Based Screening System for 3,4‐Methylenedioxymethamphetamine in Ecstasy Tablets Using a Portable Near‐Infrared Spectrometer
Author(s) -
Tsujikawa Kenji,
Yamamuro Tadashi,
Kuwayama Kenji,
Kanamori Tatsuyuki,
Iwata Yuko T.,
Miyamoto Kazuna,
Kasuya Fumiyo,
Inoue Hiroyuki
Publication year - 2016
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.13122
Subject(s) - mdma , ecstasy , diluent , chemistry , pharmacology , psychology , medicine , psychiatry , nuclear chemistry
This is the first report on development of a library search‐based screening system for 3,4‐methylenedioxymethamphetamine ( MDMA ) in ecstasy tablets using a portable near‐infrared ( NIR ) spectrometer. The spectrum library consisted of spectra originating from standard substances as well as mixtures of MDMA hydrochloride ( MDMA ‐ HC l) and diluents. The raw NIR spectra were mathematically pretreated, and then, a library search was performed using correlation coefficient. To enhance the discrimination ability, the wavelength used for the library search was limited. Mixtures of MDMA ‐ HC l and diluents were used to decide criteria to judge MDMA ‐positive or MDMA ‐negative. Confiscated MDMA tablets and medicinal tablets were used for performance check of the criteria. Twenty‐two of 27 MDMA tablets were truly judged as MDMA ‐positive. Five false‐negative results may be caused by compounds not included in the library. No false‐positive results were obtained for medicinal tablets. This system will be a useful tool for on‐site screening of MDMA tablets.