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Measurement of Postmortem 1,5‐anhydroglucitol in Vitreous Humor for Forensic Diagnosis
Author(s) -
Takata Tomoyo,
Yamasaki Yukie,
Kitao Takashi,
Miyaishi Satoru
Publication year - 2016
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.12963
Subject(s) - cerebrospinal fluid , postmortem changes , forensic science , time of death , medicine , forensic pathology , pathology , autopsy , ophthalmology , emergency medicine , veterinary medicine
In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5‐anhydroglucitol (1,5‐ AG ) concentrations in plasma and cerebrospinal fluid ( CSF ) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5‐ AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5‐ AG concentrations in vitreous humor (mean± SD : 20.2 ± 8.7 μg/ mL ) and CSF (16.8 ± 8.7 μg/ mL ) did not differ significantly and showed a strong correlation ( r 2 = 0.87, p < 0.01). These results suggest that the vitreous humor 1,5‐ AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5‐ AG concentration.