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Forensic Informativity of ~3000 bp of Coding Sequence of Domestic Dog mt DNA
Author(s) -
Angleby Helen,
Oskarsson Mattias,
Pang Junfeng,
Zhang Yaping,
Leitner Thomas,
Braham Caitlyn,
Arvestad Lars,
Lundeberg Joakim,
Webb Kristen M.,
Savolainen Peter
Publication year - 2014
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/1556-4029.12504
Subject(s) - mitochondrial dna , haplotype , coding region , genetics , biology , phylogenetic tree , population , mtdna control region , genome , evolutionary biology , gene , demography , genotype , sociology
The discriminatory power of the noncoding control region ( CR ) of domestic dog mitochondrial DNA alone is relatively low. The extent to which the discriminatory power could be increased by analyzing additional highly variable coding regions of the mitochondrial genome (mtGenome) was therefore investigated. Genetic variability across the mtGenome was evaluated by phylogenetic analysis, and the three most variable ~1 kb coding regions identified. We then sampled 100 Swedish dogs to represent breeds in accordance with their frequency in the Swedish population. A previously published dataset of 59 dog mtGenomes collected in the United States was also analyzed. Inclusion of the three coding regions increased the exclusion capacity considerably for the Swedish sample, from 0.920 for the CR alone to 0.964 for all four regions. The number of mt DNA types among all 159 dogs increased from 41 to 72, the four most frequent CR haplotypes being resolved into 22 different haplotypes.

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