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Effects of Guideline and Formulary Changes on Statin Prescribing in the Veterans Affairs
Author(s) -
Markovitz Adam A.,
Holleman Rob G.,
Hofer Timothy P.,
Kerr Eve A.,
Klamerus Mandi L.,
Sussman Jeremy B.
Publication year - 2017
Publication title -
health services research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.706
H-Index - 121
eISSN - 1475-6773
pISSN - 0017-9124
DOI - 10.1111/1475-6773.12788
Subject(s) - formulary , veterans affairs , medicine , guideline , statin , medline , family medicine , emergency medicine , medical emergency , political science , pathology , law
Objective To compare the effects of two sequential policy changes—the addition of a high‐potency statin to the Department of Veterans Affairs ( VA ) formulary and the release of the American College of Cardiology/American Heart Association ( ACC / AHA ) cholesterol guidelines—on VA provider prescribing. Data Sources/Study Setting Retrospective analysis of 1,100,682 VA patients, 2011–2016. Study Design Interrupted time‐series analysis of changes in prescribing of moderate‐to‐high‐intensity statins among high‐risk patients and across high‐risk subgroups. We also assessed changes in prescribing of atorvastatin and other statin drugs. We estimated marginal effects ( ME ) of formulary and guideline changes by comparing predicted and observed statin use. Data Collection/Extraction Methods Data from VA Corporate Data Warehouse. Principal Findings The use of moderate‐to‐high‐intensity statins increased by 2 percentage points following the formulary change ( ME , 2.4, 95% confidence interval [ CI ], 2.2 to 2.6) and less than 1 percentage point following the guideline change ( ME , 0.8, 95% CI , 0.6 to 0.9). The formulary change led to approximately a 12 percentage‐point increase in the use of moderate‐to‐high‐intensity atorvastatin ( ME , 11.5, 95% CI , 11.3 to 11.6). The relatively greater provider response to the formulary change occurred across all patient subgroups. Conclusions Addition of a high‐potency statin to formulary affected provider prescribing more than the ACC / AHA guidelines.