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Colposcopic assessment by Swedescore, evaluation of effectiveness in the Swedish screening programme: a cross‐sectional study
Author(s) -
Alfonzo Emilia,
Holmberg Erik,
Milsom Ian,
Strander Björn
Publication year - 2022
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.17054
Subject(s) - colposcopy , medicine , cervical intraepithelial neoplasia , referral , cross sectional study , obstetrics , gynecology , squamous intraepithelial lesion , biopsy , cytology , odds ratio , cervical screening , cervical cancer , logistic regression , cancer , radiology , family medicine , pathology
Objective To evaluate the effectiveness and performance of Swedescore in the Swedish screening programme. Design Cross‐sectional register study. Setting and Population All Swedish women aged over 18 years with a colposcopic assessment linked to a biopsy in the Swedish National Cervical Screening Registry, 2015–20. Methods Colposcopies with Swedescore were compared with the histopathological diagnosis of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). The respective influence of cytology and human papillomavirus (HPV) testing, at referral for colposcopy and concurrently with colposcopy, were investigated in regression models. Main Outcome Measures CIN2+. Results A total of 11 317 colposcopic assessments with Swedescore were included. Odds ratios for CIN2+ increased for every step in the Swedescore scale. At Swedescore ≥0–1, the proportion of CIN2+ was 9.8%. At Swedescore ≥8, the specificity was 93.3% and the positive predictive value was 60.1%, Area under the receiver operating characteristics curve (AUC) was 0.71. If the smear had been abnormal at referral, a normal colposcopy (Swedescore 0–1) was still associated with a CIN2+ risk of more than 5%. In the regression model, cytology and HPV had higher odds ratio for CIN2+ than colposcopy; the combination resulted in an AUC of 0.88. Conclusions Swedescore works well in a routine clinical setting but colposcopy assessed with Swedescore was inferior to that reported in previous clinical studies. No safe cutoff level was identified for refraining from biopsy. See‐and‐treat at Swedescore 8–10 is feasible only if referral cytology showed high‐grade squamous intraepithelial lesion. Tweetable Abstract No safe cutoff level for refraining from biopsy nor for see‐and‐treat with Swedescore.