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Extending the window for thrombolysis for treatment of acute ischaemic stroke during pregnancy: a review
Author(s) -
Dinehart E,
Leon Guerrero C,
Pham A,
Chandra S,
Petersen SM,
Bathgate S,
Ahmadzia H
Publication year - 2021
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.16495
Subject(s) - thrombolysis , neuroimaging , medicine , ischaemic stroke , tissue plasminogen activator , pregnancy , recombinant tissue plasminogen activator , stroke (engine) , acute stroke , therapeutic window , ischemia , ischemic stroke , psychiatry , mechanical engineering , biology , myocardial infarction , engineering , genetics , modified rankin scale , pharmacology
Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt‐PA) for the treatment of acute ischaemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt‐PA for treatment of AIS in a pregnant patient within an extended‐time window (>4.5 hours, and <9 hours) based on advanced neuroimaging with a favourable outcome. Tweetable abstract Novel use of IV rt‐PA for treatment of AIS in pregnancy within an extended‐time window based on advanced imaging with a favourable outcome.