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Objective  To evaluate how hysterectomy affects the prescription of analgesic, psychotropic and neuroactive drugs in women with endometriosis using population‐based nationwide registers.    Design  Nationwide cohort study.    Setting  Swedish national registers, from 1 January 2009 to 31 December 2018.    Population  Women with benign disease undergoing a total hysterectomy during the 4‐year period of 2012–2015. Women with endometriosis ( n  = 1074) were identified and compared with women who did not have endometriosis ( n  = 10 890).    Methods  Prospectively collected data from two population‐based registers were linked: the Swedish National Quality Register of Gynaecological Surgery and the Swedish National Drug Register. Multivariate logistic regression was used as the main statistical method.    Main outcome measures  Changes in drug prescription over time for 3 years prior to and 3 years after hysterectomy.    Results  The frequency of prescription of analgesics was higher in women with endometriosis compared with women without endometriosis (OR 2.2, 95% CI 1.7–2.9). Among women with endometriosis, the prescription of analgesics (OR 1.0, 95% CI 0.8–1.2) did not decrease 3 years after hysterectomy compared with the 3 years prior to surgery. There was also a significantly higher rate of prescription of psychoactive (OR 1.6, 95% CI 1.4–2.0) and neuroactive drugs (OR 1.9, 95% CI 1.3–2.7) in the long term postoperatively.    Conclusions  In women undergoing hysterectomy, endometriosis was associated with a higher prescription rate of analgesics. In the endometriosis group the prescription of analgesic, psychoactive and neuroactive drugs did not decrease when comparing prescription rates for the 3 years prior to and the 3 years after surgery.    Tweetable abstract  In women with endometriosis, the long‐term prescription of analgesics did not decrease after hysterectomy.

Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in women with endometriosis: nationwide cohort study