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Sex is associated with the persistence of non‐optimal vaginal microbiota following treatment for bacterial vaginosis: a prospective cohort study
Author(s) -
Ratten LK,
Plummer EL,
Murray GL,
Danielewski J,
Fairley CK,
Garland SM,
Hocking JS,
Tachedjian G,
Chow EPF,
Bradshaw CS,
Vodstrcil LA
Publication year - 2021
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.16430
Subject(s) - bacterial vaginosis , gardnerella vaginalis , population , prospective cohort study , lactobacillus , relative species abundance , medicine , cohort study , amplicon sequencing , biology , gynecology , obstetrics , abundance (ecology) , ecology , bacteria , 16s ribosomal rna , environmental health , genetics
Objective Determine the associations between factors and sexual practices and the composition of the vaginal microbiome (VM) of women treated for bacterial vaginosis (BV). Design Prospective cohort study. Setting The Melbourne Sexual Health Centre, Melbourne, Australia. Population Seventy‐five reproductive‐age women diagnosed with clinical BV, treated with first‐line antibiotics and followed for up to 6 months. Methods Women self‐collected vaginal swabs and completed questionnaires at enrolment, the day following antibiotics and monthly for up to 6months until BV recurrence or no BV recurrence ( n = 430 specimens). Bacterial composition was determined using 16S rRNA gene amplicon sequencing. The effects of ongoing factors on VM composition (utilising 291 monthly specimens) were assessed using generalised estimating equations population‐averaged models, which accounted for repeated measures within individuals. Main outcome measures The relative abundance of vaginal bacterial taxa. Results Women who reported ongoing sex with a regular sexual partner (RSP) had a VM comprised of increased relative abundance of non‐optimal BV‐associated bacteria (Adjusted co‐efficient [Adjusted co‐eff] = 11.91, 95% CI 3.39to20.43, P = 0.006) and a decreased relative abundance of optimal, Lactobacillus species (Adjusted co‐eff = −12.76, 95% CI −23.03 to −2.49, P = 0.015). A history of BV was also associated with a decreased relative abundance of Lactobacillus spp. (Adjusted co‐eff = −12.35, 95% CI −22.68, P = 0.019). The relative abundance of Gardnerella, Atopobium and Sneathia spp. increased following sex with an RSP. Conclusions Sex with an untreated RSP after BV treatment was associated with a VM comprised of non‐optimal BV‐associated bacteria. BV treatment approaches may need to include partner treatment if they are to achieve a sustained optimal VM associated with improved health outcomes. Tweetable abstract Sex drives a return to a ‘non‐optimal’ vaginal microbiota after antibiotics for bacterial vaginosis.