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The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review
Author(s) -
Kremer WW,
Steenbergen RDM,
Heideman DAM,
Kenter GG,
Meijer CJLM
Publication year - 2021
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.16395
Subject(s) - cervical intraepithelial neoplasia , triage , dna methylation , cervical cancer , methylation , oncology , medicine , colposcopy , carcinogenesis , gynecology , obstetrics , cancer , biology , gene , genetics , gene expression , emergency medicine
This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high‐risk HPV (hrHPV) ‐positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV‐positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN. Tweetable abstract This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high‐risk HPV infection.