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Laparoscopic ablation or excision with helium thermal coagulator versus electrodiathermy for the treatment of mild‐to‐moderate endometriosis: randomised controlled trial
Author(s) -
Misra G,
Sim J,
ElGizawy Z,
Watts K,
Jerreat S,
Coia T,
Ritchie J,
O'Brien S
Publication year - 2020
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.16279
Subject(s) - medicine , endometriosis , laparoscopy , surgery , visual analogue scale , quality of life (healthcare) , randomized controlled trial , blood loss , pelvic pain , population , environmental health , nursing
Objective To compare electrodiathermy with helium thermal coagulation in laparoscopic treatment of mild‐to‐moderate endometriosis. Design Parallel‐group randomised controlled trial. Setting A UK endometriosis centre. Population Non‐pregnant women aged 16–50 years with a clinical diagnosis of mild‐to‐moderate endometriosis. Methods If mild or moderate endometriosis was confirmed at laparoscopy, women were randomised to laparoscopic treatment with electrodiathermy or helium thermal coagulator. Main outcome measures Cyclical pain and dyspareunia (rated on a 100‐mm visual analogue scale, VAS), quality of life at baseline and at 6, 12 and 36 weeks following surgery, operative blood loss and surgical complications. Results A total of 192 women were randomised. Of these, 155 (81%) completed the primary outcome point at 12 weeks. In an intention‐to‐treat analysis, VAS scores for cyclical pain were significantly lower in the electrodiathermy group compared with the helium group at 12 weeks (mean difference, 9.43 mm; 95% CI 0.46, 18.40 mm; P = 0.039) and across all time points (mean difference, 10.13 mm; 95% CI 3.48, 16.78 mm; P = 0.003). A significant difference in dyspareunia also favoured electrodiathermy at 12 weeks (mean difference, 11.66 mm; 95% CI 1.39, 21.93 mm; P = 0.026). These effects were smaller than the proposed minimum important difference of 18.00 mm, however. Differences in some aspects of quality of life favoured electrodiathermy. There was no significant difference in operative blood loss (fold‐change with helium as reference, 1.43; 95% CI 0.96, 2.15; P = 0.081). Conclusions Although electrodiathermy was statistically superior to helium ablation in reducing cyclical pain and dyspareunia, these effects may be too small to be clinically significant. Tweetable abstract Helium coagulation is not superior to electrodiathermy in laparoscopic treatment of mild‐to‐moderate endometriosis.