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Patterns of clinicopathological features and outcome in epithelial ovarian cancer patients: 35 years of prospectively collected data
Author(s) -
Irodi A,
Rye T,
Herbert K,
Churchman M,
Bartos C,
Mackean M,
Nussey F,
Herrington CS,
Gourley C,
Hollis RL
Publication year - 2020
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.16264
Subject(s) - medicine , debulking , serous fluid , stage (stratigraphy) , gastroenterology , ovarian cancer , incidence (geometry) , prospective cohort study , survival analysis , overall survival , oncology , cancer , surgery , paleontology , physics , optics , biology
Objective Investigate the clinical landscape of ovarian carcinoma (OC) over time. Design Register‐based prospectively collected data. Setting South East Scotland. Sample A total of 2805 OC patients diagnosed in 1981–2015. Methods Survival times were visualised using the Kaplan–Meier method; median survival, 5‐year survival probabilities and associated restricted mean survival time analyses were used to quantify survival differences. Main outcome measures Disease‐specific survival. Results A significant increase in disease‐specific survival (DSS) from 1981–1985 to 2011–2015 was observed (median 1.73 versus 4.23 years, P < 0.0001). Corresponding increase in progression‐free survival (PFS) was not statistically significant (median 1.22 versus 1.58 years, P = 0.2568). An increase in the proportion of cases with low residual disease volume (RD) (<2 cm RD) following debulking was observed (54.0% versus 87.7%, P < 0.0001). The proportion of high grade serous (HGS) cases increased ( P < 0.0001), whereas endometrioid and mucinous cases decreased ( P = 0.0005 and P = 0.0002). Increases in stage IV HGS OC incidence ( P = 0.0009) and stage IV HGS OC DSS ( P = 0.0122) were observed. Increasing median age at diagnosis correlated with increasing Eastern Cooperative Oncology Group Performance Status (ECOG PS) over time ( r = 0.86). Conclusions OC DSS has improved over the last 35 years. PFS has not significantly increased, highlighting that improvement in outcome has been limited to extending post‐relapse survival. Distribution of stage at diagnosis, histological subtype and RD following debulking has changed over time, reflecting evolution in tumour classification, staging and optimal debulking definitions (from low RD to minimal or zero RD). Histology, stage, RD and ECOG PS remain reliable outcome predictors. Increasing median age at diagnosis and ECOG PS indicates demographic shifts in the clinical population. Tweetable abstract Significant improvement in ovarian carcinoma survival has been seen over time. Most of this improvement is due to an extension of survival following disease relapse.