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Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta‐analysis
Author(s) -
Grzeskowiak LE,
Smithers LG,
Amir LH,
Grivell RM
Publication year - 2018
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.15177
Subject(s) - domperidone , medicine , breast milk , placebo , meta analysis , adverse effect , odds ratio , breast feeding , breastfeeding , obstetrics , randomized controlled trial , pediatrics , biochemistry , alternative medicine , pathology , dopamine , chemistry
Background Mothers of preterm infants often struggle to produce enough breast milk to meet the nutritional needs of their infant. Galactagogues such as domperidone are often prescribed to increase breast milk supply but evidence supporting their role in clinical practice is uncertain. Objective To evaluate the efficacy and safety of domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants. Search strategy MEDLINE , Embase and Web of Science were searched without language restrictions from first publication until January 2017. Bibliographies of articles and reviews were hand‐searched for additional reports. Selection criteria Randomised controlled trials that compared domperidone with placebo in mothers of preterm infants (<37 weeks’ gestation) experiencing insufficient milk supply. Data collection and analysis Two review authors independently assessed studies for inclusion, extracted data and evaluated study quality. Differences in breast milk volume and adverse events were combined using fixed effects meta‐analysis. Main results The pooled analysis of five trials consisting of 194 women demonstrated a moderate increase in daily breast milk volume of 88.3 ml/day (95% CI 56.8–119.8) with the use of domperidone compared with placebo. No difference was evident with respect to maternal adverse events (odds ratio 1.05, 95% CI 0.65–1.71), with no reported cases of prolonged QT c syndrome or sudden cardiac death. Sensitivity analyses showed no important differences in the estimates of effects. Conclusions Domperidone is well tolerated and results in a moderate short‐term increase in expressed breast milk volume among mothers of preterm infants previously identified as having insufficient breast milk supply. Tweetable abstract Domperidone leads to short‐term improvements in breast milk volume in mothers of preterm infants.