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The role of NF κ B in the three stages of pregnancy – implantation, maintenance, and labour: a review article
Author(s) -
Sakowicz A
Publication year - 2018
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.15172
Subject(s) - chemokine , pregnancy , cytokine , nf κb , immune system , transcription factor , gestation , nfkb1 , biology , immunology , medicine , endocrinology , microbiology and biotechnology , inflammation , gene , genetics
The transcription factor nuclear factor kappa B ( NF κ B) controls the expression of over 400 genes, some of which are associated with reproductive events. During implantation, immune cells accumulate in the maternal–fetal interface; they secrete inflammatory mediators under the control of NFĸB , the level of which also rises. NFĸB is then downregulated to maintain gestation, but its level rises again before birth to manage prostaglandin, cytokine, and chemokine synthesis, and to stimulate uterine contraction. This review summarises the current state of knowledge about NF κ B and its role in the molecular regulation of processes related to pregnancy development. Tweetable abstract This review examines the current state of knowledge about role of NF κ B in the development of pregnancy.