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Cardiorespiratory fitness, exercise haemodynamics and birth outcomes: the Coronary Artery Risk Development in Young Adults Study
Author(s) -
LaneCordova AD,
Carnethon MR,
Catov JM,
Montag S,
Lewis CE,
Schreiner PJ,
Dude A,
Sternfeld B,
Badon SE,
Greenland P,
Gunderson EP
Publication year - 2018
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.15146
Subject(s) - medicine , cardiorespiratory fitness , small for gestational age , blood pressure , gestational age , population , pregnancy , obstetrics , cardiology , environmental health , biology , genetics
Objective Determine associations of cardiorespiratory fitness, exercise systolic blood pressure ( SBP ) and heart rate recovery ( HRR ) following a maximal exercise test performed years preceding pregnancy with odds of preterm birth ( PTB ; <37 weeks' gestation) and small for gestational age ( SGA ; birthweight <10 th percentile) delivery. Design Prospective, longitudinal .Setting Multi‐site, observational cohort study initially consisting of 2787 black and white women aged 18–30 at baseline (1985–86) and followed for 25 years (Y25; 2010–2011). Population 768 nulliparous women at baseline who reported ≥1 live birth by the Y25 exam. Methods We used Poisson regression to determine associations of exposures with PTB / SGA . Main outcome measures PTB and/or SGA births. Results Women with PTB ( n = 143) and/or SGA ( n = 88) were younger, had completed fewer years of education and were more likely to be black versus women without PTB / SGA ( n = 546). Women with PTB / SGA had lower fitness (501 ± 9 versus 535 ± 6 seconds, P < 0.002) and higher submaximal SBP than women without PTB / SGA (144 ± 1 versus 142 ± 1 mmHg, P < 0.04). After adjustment, no exercise test variables were associated with PTB / SGA , though the association with HRR and submaximal SBP approached significance in the subset of women who completed the exercise test <5 years before the index birth. Conclusions Neither fitness nor haemodynamic responses to exercise a median of 5 years preceding pregnancy, were associated with PTB / SGA . These findings indicate excess likelihood of PTB / SGA is not detectable by low fitness or exercise haemodynamic responses 5 years preceding pregnancy, but exercise testing, especially HRR and submaximal SBP , may be more useful when conducted closer to the onset of pregnancy. Tweetable abstract Exercise testing conducted >5 years before pregnancy may not detect women likely to have PTB / SGA .