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Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study
Author(s) -
Catov JM,
Muldoon MF,
Reis SE,
Ness RB,
Nguyen LN,
Yamal JM,
Hwang H,
Parks WT
Publication year - 2018
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.15040
Subject(s) - medicine , pregnancy , obstetrics , prospective cohort study , placenta , chorioamnionitis , gestation , fetus , genetics , biology
Objective Preterm birth ( PTB ) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected. Design Pregnancy cohort study. Setting Pittsburgh, PA , USA . Population Women with PTB ( n = 115) and term births ( n = 210) evaluated 4–12 years after pregnancy. Methods Cardiometabolic risk markers were compared in women with prior PTB versus term births; pre‐eclampsia and growth restriction cases were excluded. Placental evidence of maternal vascular malperfusion (vasculopathy, infarct, advanced villous maturation, perivillous fibrin, intervillous fibrin deposition), acute infection/inflammation (chorioamnionitis, funisitis, deciduitus) and villitis of unknown aetiology (chronic inflammation) was used to classify PTB s. Main outcome measures Carotid artery intima‐media thickness ( IMT ), fasting lipids, blood pressure ( BP ) and inflammatory markers measured after delivery. Results Women with PTB and malperfusion lesions had higher total cholesterol (+13.5 mg/dl) and systolic BP (+4.0 mmHg) at follow up compared with women with term births, accounting for age, race, pre‐pregnancy BMI , and smoking ( P < 0.05). Women with PTB and malperfusion accompanied by inflammatory lesions had the most atherogenic profile after pregnancy (cholesterol +18.7, apolipoprotein B + 12.7 mg/dl; all P < 0.05), adjusted for pre‐pregnancy features. Carotid IMT was higher in this group (+0.037 cm, P = 0.031) accounting for pre‐pregnancy factors; differences were attenuated after adjusting for BP and atherogenic lipids at follow up (+0.027, P = 0.095). Conclusion PTB s with placental malperfusion were associated with an excess maternal cardiometabolic risk burden in the decade after pregnancy. The placenta may offer insight into subtypes of PTB related to maternal cardiovascular disease. Tweetable abstract Preterm births with placental malperfusion may mark women at higher cardiovascular disease risk.