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The inherited risk of retained placenta: a population based cohort study
Author(s) -
Endler M,
Cnattingius S,
Granfors M,
Wikström AK
Publication year - 2018
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.14828
Subject(s) - placenta , medicine , odds ratio , obstetrics , retained placenta , population , cohort study , pregnancy , cohort , fetus , gynecology , biology , genetics , environmental health
Objective To investigate whether retained placenta in the first generation is associated with an increased risk of retained placenta in the second generation. Design Population‐based cohort study. Setting Sweden. Population Using linked generational data from the Swedish Medical Birth Register 1973–2012, we identified 494 000 second‐generation births with information on the birth of the mother (first‐generation index birth). For 292 897 of these births there was information also on the birth of the father. Methods Risk of retained placenta in the second generation was calculated as adjusted odds ratios ( aOR ) by unconditional logistic regression with 95% confidence intervals (95% CI ) according to whether retained placenta occurred in a first generation birth or not. Main outcome Retained placenta in the second generation. Results The risk of retained placenta in a second‐generation birth was increased if retained placenta had occurred at the mother's own birth ( aOR 1.66, 95% CI 1.52–1.82), at the birth of one of her siblings ( aOR 1.58, 95% CI 1.43–1.76) or both ( aOR 2.75, 95% CI 2.18–3.46). The risk was slightly increased if retained placenta had occurred at the birth of the father ( aOR 1.23, 95% CI 1.07–1.41). For preterm births in both generations, the risk of retained placenta in the second generation was increased six‐fold if retained placenta had occurred at the mother's birth ( OR 6.55, 95% CI 2.68–16.02). Conclusion There is an intergenerational recurrence of retained placenta on the maternal and most likely also on the paternal side. The recurrence risk seems strongest in preterm pregnancies. Tweetable abstract A population‐based cohort study suggests that there is an intergenerational recurrence of retained placenta.