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Changes in anti‐müllerian hormone levels as a biomarker for ovarian reserve after ultrasound‐guided high‐intensity focused ultrasound treatment of adenomyosis and uterine fibroid
Author(s) -
Lee JS,
Hong GY,
Lee KH,
Kim TE
Publication year - 2017
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.14739
Subject(s) - adenomyosis , medicine , uterine fibroids , ablation , high intensity focused ultrasound , ovarian reserve , ultrasound , radiology , gynecology , endometriosis , urology , infertility , pregnancy , genetics , biology
Objective To assess the changes in antimüllerian hormone ( AMH ) levels after ablation for symptomatic uterine fibroids and adenomyosis using ultrasound‐guided high‐intensity focused ultrasound ( US g HIFU ). Design A prospective study. Setting Gynaecological department in multiple hospitals in South Korea. Population Patients with uterus fibroids and adenomyosis. Methods Seventy‐nine women with symptomatic uterine fibroids and adenomyosis who met the inclusion criteria were enrolled in our study between January 2014 and December 2014. All patients underwent US g HIFU ablations. Each patient was examined before and after treatment, and at 6 and 12 months after treatment by T2‐weighted MRI imaging (T2 WI ) and T1‐weighted MRI imaging (T1 WI ) with gadolinium injection. Symptom severity scores ( SSS ), Uterine Fibroid Symptom Quality of Life ( UFS ‐ QOL ) questionnaire subscales, and reductions of treated volume were assessed. AMH levels before and 6 months after HIFU ablation were compared to determine whether US g HIFU ablation affected ovarian reserve. Main outcome measures HIFU treatment did not affect the ovarian function. Results HIFU treatment time (mean ± standard deviation), HIFU ablation time, and treatment energy were 73.5 ± 25.6 minutes, 9994.7 ± 386.8 seconds, and 364 713.8 ± 156 350.7 Joules, respectively. AMH levels before and 6 months after HIFU ablation were 2.11 ± 2.66 and 1.84 ± 2.57 μ g/l, respectively. There was no significant difference in AMH level between the two time points ( P > 0.05). Conclusions US g HIFU ablation for uterine fibroid and adenomyosis was effective without affecting ovarian reserve. Tweetable abstract HIFU ablation is a safe and effective treatment for patients with uterine fibroids and adenomyosis that does not affect ovarian function.