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Direct aspiration versus follicular flushing in poor responders undergoing intracytoplasmic sperm injection: a randomised controlled trial
Author(s) -
Haydardedeoglu B,
Gjemalaj F,
Aytac PC,
Kilicdag EB
Publication year - 2017
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.14629
Subject(s) - follicle , intracytoplasmic sperm injection , follicular phase , medicine , flushing , pregnancy rate , oocyte , andrology , gynecology , pregnancy , ovarian follicle , in vitro fertilisation , biology , endocrinology , embryo , microbiology and biotechnology , genetics
Objective To compare follicle flushing three times with direct follicular aspiration in poor responders. Our hypothesis was that follicle flushing three times in poor responders would result in similar oocyte yield compared with direct aspiration in poor responders. Design A randomised controlled trial performed between January 2015 and June 2015. Setting University hospital. Population or sample Eighty eligible poor responders, who were defined as having five or fewer follicles ≥13 mm in average diameter with at least two follicles having maximum diameters >17 mm on the day of human chorionic gonadotrophin administration. Monofollicular cycles, including natural cycles, were excluded from the current trial. Methods In the double‐lumen needle group, oocyte retrieval was performed by flushing three times with 2 ml in each follicle and in the single‐lumen group direct follicle aspiration was performed. Main outcome measure Number of metaphase II oocytes retrieved. Results The mean number of metaphase II oocytes was similar in both groups (1.9 ± 0.1 versus 2.1 ± 0.1, respectively). The clinical pregnancy and live birth rates were similar in both groups (32.5% versus 25% and 25% versus 22.5%, respectively). The only significant difference between the two groups was the duration of oocyte retrieval (178.4 ± 13.4 versus 236.3 ± 24.1 seconds, respectively, P = 0.01). Conclusion Follicular flushing is time consuming and has similar results compared with direct follicle aspiration in poor responders. Tweetable abstract Direct follicle aspiration versus flushing in poor responders yields similar metaphase II oocytes.