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Association of severe placental inflammation with death prior to discharge and cerebral palsy in preterm infants
Author(s) -
Huetz N,
Triau S,
Leboucher B,
Sentilhes L,
Hanf M,
Nguyen S,
Flamant C,
Roze JC,
Gascoin G
Publication year - 2016
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.14177
Subject(s) - medicine , cerebral palsy , odds ratio , gestational age , population , pediatrics , gestation , obstetrics , cohort , cohort study , retrospective cohort study , pregnancy , physical therapy , environmental health , biology , genetics
Objective The objective of our study was to identify placental patterns associated with death before discharge or cerebral palsy in a large cohort of preterm infants with a high follow‐up rate at 2 years of corrected age. Design Population‐based monocentric study. Settings Monocentric study in the maternity unit of the University Hospital of Angers, France between 24 +0 and 33 +6 weeks of gestation, between January 2008 and December 2011. Population All singleton infants born alive with a placental examination were eligible. Methods Clinical data (obstetric and neonatal) were collected prospectively through the LIFT cohort. Placental data were collected retrospectively from medical records. The main outcome measure was death before discharge or cerebral palsy. Results We did not find any significant association between severe inflammatory lesions on the placenta and death [odds ratio ( OR ) 1.49; 95% CI 0.55–4.01; P = 0.43] or cerebral palsy ( OR 1.41; 95% CI 0.43–4.62; P = 0.57). This lack of significant association persisted even after adjustment ( aOR 0.9; 95% CI 0.20–2.30; P = 0.54; aOR 0.98; 95% CI 0.27–3.58; P = 0.97). Conclusion Our results do not provide evidence for a significant association between severe inflammatory placental lesions and either death before discharge or cerebral palsy at 2 years of corrected age in preterm infants born at <34 weeks of gestational age. Further studies remain necessary to confirm this result. Tweetable abstract We found no significant association between inflammatory placental lesions and death or cerebral palsy.