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Low dose aspirin and pregnancy: how important is aspirin resistance?
Author(s) -
Navaratnam K,
Alfirevic A,
Alfirevic Z
Publication year - 2016
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.13914
Subject(s) - aspirin , medicine , pregnancy , coronary artery disease , eclampsia , disease , biology , genetics
Antiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta‐analysis indicates that low‐dose aspirin causes a 10% risk reduction in pre‐eclampsia for women at high individual risk. However, in the last 15 years it has emerged that a significant proportion of aspirin‐treated individuals exhibit suboptimal platelet response, determined biochemically and clinically, termed ‘aspirin non‐responsiveness’, ‘aspirin resistance’ and ‘aspirin treatment failure’. More recently, investigation of aspirin responsiveness has begun in pregnant women. This review explores the history and clinical relevance of ‘aspirin resistance’ applied to high‐risk obstetric populations. Tweetable abstract Is ‘aspirin resistance’ clinically relevant in high‐risk obstetrics?