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External validation of the paediatric risk of malignancy index
Author(s) -
Hermans AJ,
Kluivers KB,
Massuger LF,
Coppus SF
Publication year - 2016
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.13253
Subject(s) - receiver operating characteristic , medicine , malignancy , area under the curve , prospective cohort study , population , discriminative model , body mass index , clinical practice , physical therapy , machine learning , computer science , environmental health
Objective This study aimed to validate the paediatric risk of malignancy index ( PRMI ), as previously published. Design External validation study. Setting Academic hospital: Radboud University Medical Center. Population Female paediatric patients under the age of 18 years diagnosed with, or treated for, an adnexal mass between January 1999 and October 2013. Methods Information was collected on diagnosis, presenting symptoms, and signs and imaging characteristics. The PRMI was calculated for each patient. Sensitivity, specificity, and positive and negative predictive values were calculated, and the results were visualised using a receiver operating characteristic curve ( ROC curve). Main outcome measures Histological diagnosis, discriminative performance using the area under the curve ( AUC ) of the ROC curve and sensitivity and specificity. Results Seventy‐eight patients were included, with a median age of 12 years. A malignant mass was found in 17 patients (21.8%). The PRMI with a cut‐off value of 7 resulted in a sensitivity of 70.1% (95% CI 44.1–89.6%) and a specificity of 85.3% (95% CI 73.8–93.0%). The area under the ROC curve was 0.868 (95% CI 0.756–0.980). Conclusions The PRMI showed less discriminative capacity than originally published, but its performance was still good; however, further prospective validation studies are needed to define whether the model is useful in daily clinical practice.