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Association between serum 25‐hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression
Author(s) -
Fu CW,
Liu JT,
Tu WJ,
Yang JQ,
Cao Y
Publication year - 2015
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.13111
Subject(s) - medicine , postpartum depression , edinburgh postnatal depression scale , childbirth , obstetrics , depression (economics) , cohort , postpartum period , cohort study , pregnancy , genetics , macroeconomics , economics , biology
Objective To assess the possible relationship between serum levels of 25[ OH ]D (25‐hydroxyvitamin D) collected 24 hours after delivery and postpartum depression in a Chinese cohort sample. Design Cohort study. Setting One city hospital in Beijing, China. Population Women delivering a full‐term, singleton, live‐born infant at one city hospital in Beijing between August 2013 and November 2013. Methods Women were enrolled immediately postpartum. A blood sample was obtained 24–48 hours after childbirth to test serum levels of 25[ OH ]D. Participation consisted of a visit to an obstetric unit 3 months after delivery. Main outcome measure At 3 months' postpartum, women were screened for depression using the Edinburgh Postnatal Depression Scale ( EPDS ). The primary outcome measure was a prespecified EPDS score of ≥12. Results During the study period, 323 women were admitted. In all, 248 agreed to enrol and 213 completed 3 months' follow‐up (21 were lost to follow‐up and 14 withdrew). Of the 213 women who were included, 26 (12.2%) were considered to meet criteria for postpartum depression. Serum 25[ OH ]D levels in women with no postpartum depression were significantly higher than those in women with postpartum depression ( P < 0.0001). Based on the receiver operating characteristic curve, the optimal cutoff value for serum 25[ OH ]D level as an indicator for screening for postpartum depression was estimated to be 10.2 ng/ml, with an area under the curve of 0.801 (95% CI 0.704–0.896). In multivariate analysis, there was an increased risk of postpartum depression associated with 25[ OH ]D levels ≤10.2 ng/ml ( OR 7.17, 95% CI 3.81–12.94; P < 0.0001) after adjusting for possible confounders. Conclusion Our study demonstrated that lower serum 25[ OH ]D levels were associated with postpartum depression. This association was independent of other possible variables.