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Genetic variants and risk of cervical cancer: epidemiological evidence, meta‐analysis and research review
Author(s) -
Zhang X,
Zhang L,
Tian C,
Yang L,
Wang Z
Publication year - 2014
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.12638
Subject(s) - meta analysis , odds ratio , cervical cancer , epidemiology , genetic epidemiology , medicine , confidence interval , genetic association , genetics , cancer , oncology , biology , genotype , gene , single nucleotide polymorphism
Background More than 200 articles have been published in the past 20 years on associations between genetic variants and risk of cervical cancer but the results have generally been inconsistent. Objective To provide a synopsis of the current understanding of the genetic architecture of the risk of cervical cancer by conducting a systematic review and meta‐analysis. Search strategy We conducted a systematic literature search by a two‐stage strategy using PubMed and other databases on or before 31 March 2012. Selection criteria Cross‐sectional, case–control or cohort studies about the relationship between genetic variants and cervical cancer were included. Data collection and analysis Study outcomes were presented as odds ratios (ORs) with a 95% confidence interval.We did the meta‐analysis for genetic variants which had at least three data sources and for which the significant associations were assessed using the Venice criteria. Main results A total of 5605 publications were screened, of which 286 were eligible. Meta‐analysis was conducted for 58 variants in 25 genes or loci. Fourteen variants in 11 genes or loci could increase the risk of cervical cancer and five variants in three genes or loci could decrease the risk. The epidemiological evidence of the association was graded as strong for four variants in CTLA4 and HLA DQB1 , moderate for five variants in IL‐1B , IL‐10 , XRCC3 and HLA DQA1 , and weak for 10 variants. Conclusions Many genetic variants were associated with the risk of cervical cancer as supported by the epidemiological evidence in this meta‐analysis.