English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  Intrauterine growth restriction is a cause of neonatal morbidity and mortality. A variety of definitions of low birthweight are used in clinical practice, with a lack of consensus regarding which definitions best predict adverse outcomes.    Objectives  To evaluate the relationship between birthweight standards and neonatal outcome in term‐born infants (at ≥ 37 weeks of gestation).    Search strategy   MEDLINE  (1966– J anuary 2011),  EMBASE  (1980– J anuary 2011), and the  C ochrane  L ibrary (2011:1) and MEDION were included in our search.    Selection criteria  Studies comprising live term‐born infants (gestation ≥ 37 completed weeks), with weight or other anthropometric measurements recorded at birth along with neonatal outcomes.    Data collection and analysis  Data were extracted to populate 2 × 2 tables relating birthweight standard with outcome, and meta‐analysis was performed where possible.    Main results  Twenty‐nine studies including 21 034 114 neonates were selected. Absolute birthweight was strongly associated with mortality, with birthweight < 1.5 kg giving the largest association ( OR  48.6, 95%  CI  28.62–82.53). When using centile charts, regardless of threshold, the summary odds ratios were significant but closer to 1 than when using absolute birthweight. For all tests, summary predictive ability comprised high specificity and positive likelihood ratio for neonatal death, but low sensitivity and a negative likelihood ratio close to 1.    Author's conclusions  Absolute birthweight is a prognostic factor for neonatal mortality. The indirect evidence suggests that centile charts or other definitions of low birthweight are not as strongly associated with mortality as the absolute birthweight. Further research is required to improve predictive accuracy.

bjog: an international journal of obstetrics and gynaecology

When is birthweight at term abnormally low? A systematic review and meta‐analysis of the association and predictive ability of current birthweight standards for neonatal outcomes