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Association between gestational diabetes mellitus and subsequent overactive bladder among premenopausal female twins
Author(s) -
Tettamanti G,
Iliadou AN,
Pedersen NL,
Bellocco R,
Altman D
Publication year - 2013
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/1471-0528.12253
Subject(s) - gestational diabetes , medicine , overactive bladder , body mass index , odds ratio , obstetrics , gynecology , population , diabetes mellitus , logistic regression , family history , pregnancy , endocrinology , gestation , genetics , alternative medicine , environmental health , pathology , biology
Objective To investigate the association between a history of gestational diabetes mellitus ( GDM ) and overactive bladder ( OAB ) in women of premenopausal age. Design Population‐based study. Setting The Swedish Twin Register. Population In 2005, a total of 14 094 female twins born between 1959 and 1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on GDM and OAB . The present study was designed as a cross‐sectional analysis including all women in the cohort having given birth before 2005 ( n = 7855). Methods A logistic regression model based on generalised estimating equations was used to derive odds ratios (ORs). Main outcome measure The association between a history of GDM and OAB was estimated using OR s with 95% confidence intervals ( CI s). Results The prevalence of OAB in women with a history of GDM was 19.1% compared with 10.7% in women without GDM . This corresponded to a two‐fold increased odds of OAB in women with a history of gestational diabetes ( OR 2.13, 95% CI 1.48–3.05). After adjusting the analysis for age, body mass index, parity, smoking, and diabetes mellitus, having had GDM was associated with doubled odds of OAB ( OR 1.88, 95% CI 1.26–2.80). Conclusions A history of GDM was positively associated with OAB among women of premenopausal age. The association does not seem to be mediated by body mass index or type‐I or type‐ II diabetes mellitus.