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Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes
Author(s) -
Ross Randal G.,
Olincy Ann,
Mikulich Susan K.,
Radant Allen D.,
Harris Josette G.,
Waldo Merilyne,
Compag Nina,
Heinlein Shari,
Leonard Sherry,
Zerbe Gary O.,
Adler Lawrence,
Freedman Robert
Publication year - 2002
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/1469-8986.3960809
Subject(s) - endophenotype , smooth pursuit , psychology , proband , first degree relatives , schizophrenia (object oriented programming) , audiology , developmental psychology , psychosis , eye movement , neuroscience , psychiatry , family history , cognition , medicine , mutation , genetics , biology , gene
Abnormalities during a smooth pursuit eye movement task (SPEM) are common in schizophrenic patients and their relatives. This study assessed various components of SPEM performance in first‐degree unaffected relatives of schizophrenic patients. One hundred individuals with schizophrenia, 137 unaffected first‐degree relatives, and 69 normal controls completed a 16.7°/s SPEM task. Smooth pursuit gain, catch‐up saccades (CUS), large anticipatory saccades, and leading saccades (LS) were identified. Groups were compared with parametric and admixture analyses. Schizophrenic patients performed more poorly than unaffected relatives and normals on gain, CUS, and LS. Unaffected relatives were more frequently impaired than normals only on gain and LS. Relatives of childhood‐onset and adult‐onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood‐onset and adult‐onset schizophrenia.