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Saccadic inhibition among schizotypal personality disorder subjects
Author(s) -
Brenner Colleen A.,
McDowell Jennifer E.,
Cadenhead Kristin S.,
Clementz Brett A.
Publication year - 2001
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/1469-8986.3830399
Subject(s) - psychology , schizophrenia (object oriented programming) , dorsolateral prefrontal cortex , schizotypal personality disorder , saccadic masking , prepulse inhibition , neuroscience , prefrontal cortex , audiology , psychosis , antisaccade task , eye movement , developmental psychology , cognition , psychiatry , medicine
Schizotypal personality disorder (SPD) is theoretically part of the schizophrenia spectrum both clinically and neurobiologically. A liability for developing schizophrenia may be associated with dysfunction of dorsolateral prefrontal cortex (DLPFC) and its cortical and/or subcortical circuitry. If so, abnormalities on tasks associated with DLPFC functioning among SPD subjects would support the thesis that SPD is neurobiologically related to schizophrenia. Antisaccade and ocular motor delayed response performance, both of which are ostensibly supported by DLPFC circuitry, were assessed among 29 SPD, 17 schizophrenia, and 25 normal subjects. Generally, the SPD subjects' performance was more similar to normal than to schizophrenia groups. There was evidence, however, for inhibition abnormalities in a subgroup of SPD subjects. Antisaccade performance identified more SPD subjects as “abnormal” than delayed response measures.