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Genetics and Child Psychiatry: I Advances in Quantitative and Molecular Genetics
Author(s) -
Rutter Michael,
Silberg Judy,
O'Connor Thomas,
Simonoff Emily
Publication year - 1999
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/1469-7610.00422
Subject(s) - nature versus nurture , twin study , genetics , quantitative genetics , quantitative trait locus , trait , behavioural genetics , molecular genetics , biology , statistical genetics , psychiatric genetics , psychology , genetic association , genetic linkage , evolutionary biology , genomics , heritability , genome , genetic variation , gene , psychiatry , single nucleotide polymorphism , genotype , schizophrenia (object oriented programming) , computer science , programming language
Advances in quantitative psychiatric genetics as a whole are reviewed with respect to conceptual and methodological issues in relation to statistical model fitting, new genetic designs, twin and adoptee studies, definition of the phenotype, pervasiveness of genetic influences, pervasiveness of environmental influences, shared and nonshared environmental effects, and nature‐nurture interplay. Advances in molecular genetics are discussed in relation to the shifts in research strategies to investigate multifactorial disorders (affected relative linkage designs, association strategies, and quantitative trait loci studies); new techniques and identified genetic mechanisms (expansion of trinucleotide repeats, genomic imprinting, mitochondrial DNA, fluorescent in‐situ hybridisation, behavioural phenotypes, and animal models); and the successful localisation of genes.