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Non‐ligand activation of estrous behavior in rodents: Cross‐talk at the progesterone receptor
Author(s) -
Beyer C.,
GonzálezFlores O.,
GarcíaJuárez M.,
GonzálezMariscal G.
Publication year - 2003
Publication title -
scandinavian journal of psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 72
eISSN - 1467-9450
pISSN - 0036-5564
DOI - 10.1111/1467-9450.00339
Subject(s) - second messenger system , estrous cycle , endocrinology , medicine , signal transduction , receptor , intracellular , effector , chemistry , estrogen , phosphorylation , neurotransmitter , dopamine , kinase , protein kinase a , microbiology and biotechnology , biology
Estrous behavior in rodents is triggered by the binding of progesterone (P) to its intracellular receptor (PR). Non‐steroidal agents (i.e., gonadotropin‐releasing hormone, noradrenaline, dopamine and others), acting at the membrane, can facilitate estrous behavior in estrogen‐primed rats. This action is mediated through the generation of second messengers (cyclic AMP, cyclic GMP, calcium) which, in turn, phosphorylate through diverse kinase systems (protein kinases A, G or C) either the PR or associated effector proteins linking the PR to the trans‐activation machinery. P or its metabolites also activate cyclic AMP‐signaling pathways by acting directly on the membrane or by modulating neurotransmitter release. Molecular processes resulting from second messenger signaling pathways and those from the progesterone–RP interaction synergize to elicit a full behavioral response.