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A gene to drug venture: Poisson options analysis
Author(s) -
Brach Marion A.,
Paxson Dean A.
Publication year - 2001
Publication title -
randd management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.253
H-Index - 102
eISSN - 1467-9310
pISSN - 0033-6807
DOI - 10.1111/1467-9310.00210
Subject(s) - poisson distribution , jump diffusion , log normal distribution , value (mathematics) , econometrics , statistical physics , diffusion , economics , jump , mathematical economics , mathematics , statistics , physics , thermodynamics , quantum mechanics
We provide a Poisson real option model of a gene‐to‐drug venture. First we describe a general new drug discovery programme as well as a specific secretory protein research programme. Then we model both the candidate secretory gene and the ‘hot’ gene discoveries as Poisson processes. Gene deal value sizes are modeled as lognormal distributions. Then we calculate the expected R&D value (EV) of the Poisson discoveries times the value distributions, for both stages. Finally, for generic collaborating‐funding arrangements, we show the Merton (1976) standard mixed diffusion‐jump option value, compared to a risk neutral ‘intrinsic’ value. Under simple assumptions, the real option value is substantial, even if there is no intrinsic value.