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The Neuropsychology of Down Syndrome: Evidence for Hippocampal Dysfunction
Author(s) -
Pennington Bruce F.,
Moon Jennifer,
Edgin Jamie,
Stedron Jennifer,
Nadel Lynn
Publication year - 2003
Publication title -
child development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 257
eISSN - 1467-8624
pISSN - 0009-3920
DOI - 10.1111/1467-8624.00522
Subject(s) - hippocampal formation , psychology , neuropsychology , cognition , context (archaeology) , developmental psychology , hippocampus , neuroscience , audiology , clinical psychology , medicine , paleontology , biology
This study tested prefrontal and hippocampal functions in a sample of 28 school–aged (M = 14.7 years, SD = 2.7) individuals with Down syndrome (DS) compared with 28 (M = 4.9 years, SD = .75) typically developing children individually matched on mental age (MA). Both neuropsychological domains were tested with multiple behavioral measures. Benchmark measures of verbal and spatial function demonstrated that this DS sample was similar to others in the literature. The main finding was a significant Group x Domain interaction effect indicating differential hippocampal dysfunction in the group with DS. However, there was a moderate partial correlation (r = .54, controlling for chronological age) between hippocampal and prefrontal composite scores in the DS group, and both composites contributed unique variance to the prediction of MA and adaptive behavior in that group. In sum, these results indicate a particular weakness in hippocampal functions in DS in the context of overall cognitive dysfunction. It is interesting that these results are similar to what has been found in a mouse model of DS. Such a model will make it easier to understand the neurobiological mechanisms that lead to the development of hippocampal dysfunction in DS.