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Non‐parametric group sequential designs in randomized clinical trials
Author(s) -
Bandyopadhyay Uttam,
Biswas Atanu
Publication year - 2003
Publication title -
australian and new zealand journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 41
eISSN - 1467-842X
pISSN - 1369-1473
DOI - 10.1111/1467-842x.00290
Subject(s) - mathematics , sample size determination , statistics , parametric statistics , binomial (polynomial) , nonparametric statistics , negative binomial distribution , sample (material) , binomial distribution , econometrics , poisson distribution , chemistry , chromatography
Summary This paper examines some non‐parametric group sequential designs applicable for randomized clinical trials, for comparing two continuous treatment effects taking the observations in matched pairs, or applicable in event‐based analysis. Two inverse binomial sampling schemes are considered, of which the second one is an adaptive data‐dependent design. These designs are compared with some fixed sample size competitors. Power and expected sample sizes are calculated for the proposed procedures.