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The cortex in multidimensional space: where do cortical areas come from?
Author(s) -
Kingsbury Marcy A.,
Finlay Barbara L.
Publication year - 2001
Publication title -
developmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.801
H-Index - 127
eISSN - 1467-7687
pISSN - 1363-755X
DOI - 10.1111/1467-7687.00158
Subject(s) - cortex (anatomy) , neuroscience , visual cortex , sensory system , cerebral cortex , forebrain , ocular dominance , psychology , biology , central nervous system
The concept of a cortical ‘area’ as a discrete phylogenetic, developmental and computational unit is evaluated. Evidence including the comparative organization of the forebrain in vertebrates, the organization of cortex in different mammals, the scaling of the areas of the isocortex in mammals, and the early molecular differentiation of the cortex all suggest a special status for the primary sensory cortical areas, particularly the visual cortex. Furthermore, the overlapping gradients of early molecular expression and the patterning of cortical structure and connectivity by thalamic input suggest a new view of cortical organization that is different from the traditional view of a developmentally mosaic cortex; this view proposes that distinct cortical areas arise combinatorily from the multiple overlapping processes imposed upon the developing cortex.