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Methanol metabolism in the acetogenic bacterium Acetobacterium woodii
Author(s) -
Kremp Florian,
Poehlein Anja,
Daniel Rolf,
Müller Volker
Publication year - 2018
Publication title -
environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.954
H-Index - 188
eISSN - 1462-2920
pISSN - 1462-2912
DOI - 10.1111/1462-2920.14356
Subject(s) - acetogenesis , biology , bioenergetics , bacteria , methanogenesis , methanol , biochemistry , anaerobic bacteria , methanol dehydrogenase , metabolism , enzyme , chemistry , mitochondrion , organic chemistry , genetics
Summary Methanol derived from plant tissue is ubiquitous in anaerobic sediments and a good substrate for anaerobes growing on C 1 compounds such as methanogens and acetogens. In contrast to methanogens little is known about the physiology, biochemistry and bioenergetics of methanol utilization in acetogenic bacteria. To fill this gap, we have used the model acetogen Acetobacterium woodii to study methanol metabolism using physiological and biochemical experiments paired with molecular studies and transcriptome analysis. These studies identified the genes and enzymes involved in acetogenesis from methanol and the redox carriers involved. We will present the first comprehensive model for carbon and electron flow from methanol in an acetogen and the bioenergetics of acetogenesis from methanol.