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Bangladeshi children with acute diarrhoea show faecal microbiomes with increased Streptococcus abundance, irrespective of diarrhoea aetiology
Author(s) -
Kieser Silas,
Sarker Shafiqul A.,
Sakwinska Olga,
Foata Francis,
Sultana Shamima,
Khan Zeenat,
Islam Shoheb,
Porta Nadine,
Combremont Séverine,
Betrisey Bertrand,
Fournier Coralie,
Charpagne Aline,
Descombes Patrick,
Mercenier Annick,
Berger Bernard,
Brüssow Harald
Publication year - 2018
Publication title -
environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.954
H-Index - 188
eISSN - 1462-2920
pISSN - 1462-2912
DOI - 10.1111/1462-2920.14274
Subject(s) - biology , microbiology and biotechnology , microbiome , dysbiosis , etiology , streptococcus , virulence , immunology , bacteria , medicine , gene , bioinformatics , biochemistry , genetics
Summary We report streptococcal dysbiosis in acute diarrhoea irrespective of aetiology. Compared with 20 healthy local controls, 71 Bangladeshi children hospitalized with acute diarrhoea (AD) of viral, mixed viral/bacterial, bacterial and unknown aetiology showed a significantly decreased bacterial diversity with loss of pathways characteristic for the healthy distal colon microbiome (mannan degradation, methylerythritol phosphate and thiamin biosynthesis), an increased proportion of faecal streptococci belonging to the Streptococcus bovis and Streptococcus salivarius species complexes, and an increased level of E. coli ‐associated virulence genes. No enteropathogens could be attributed to a subgroup of patients. Elevated lytic coliphage DNA was detected in 2 out of 5 investigated enteroaggregative E. coli (EAEC)‐infected patients. Streptococcal outgrowth in AD is discussed as a potential nutrient‐driven consequence of glucose provided with oral rehydration solution.