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Bacterial community collapse: a meta‐analysis of the sinonasal microbiota in chronic rhinosinusitis
Author(s) -
Wagner Mackenzie Brett,
Waite David W.,
Hoggard Michael,
Douglas Richard G.,
Taylor Michael W.,
Biswas Kristi
Publication year - 2017
Publication title -
environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.954
H-Index - 188
eISSN - 1462-2920
pISSN - 1462-2912
DOI - 10.1111/1462-2920.13632
Subject(s) - biology , actinobacteria , paranasal sinuses , propionibacterium , proteobacteria , metagenomics , corynebacterium , microbiology and biotechnology , microbiome , bacterial phyla , pyrosequencing , propionibacterium acnes , fusobacterium , bacteria , 16s ribosomal rna , pathology , genetics , bacteroides , medicine , gene
Summary Chronic rhinosinusitis (CRS) is a common, debilitating condition characterized by long‐term inflammation of the nasal cavity and paranasal sinuses. The role of the sinonasal bacteria in CRS is unclear. We conducted a meta‐analysis combining and reanalysing published bacterial 16S rRNA sequence data to explore differences in sinonasal bacterial community composition and predicted function between healthy and CRS affected subjects. The results identify the most abundant bacteria across all subjects as Staphylococcus , Propionibacterium , Corynebacterium , Streptococcus and an unclassified lineage of Actinobacteria . The meta‐analysis results suggest that the bacterial community associated with CRS patients is dysbiotic and ecological networks fostering healthy communities are fragmented. Increased dispersion of bacterial communities, significantly lower bacterial diversity, and increased abundance of members of the genus Corynebacterium are associated with CRS. Increased relative abundance and diversity of other members belonging to the phylum Actinobacteria and members from the genera Propionibacterium differentiated healthy sinuses from those that were chronically inflamed. Removal of Burkholderia and Propionibacterium phylotypes from the healthy community dataset was correlated with a significant increase in network fragmentation. This meta‐analysis highlights the potential importance of the genera Burkholderia and Propionibacterium as gatekeepers, whose presence may be important in maintaining a stable sinonasal bacterial community.