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Organization and mode of action of two component system signaling circuits from the various kingdoms of life
Author(s) -
Alvarez Adrian F.,
BarbaOstria Carlos,
SilvaJiménez Hortencia,
Georgellis Dimitris
Publication year - 2016
Publication title -
environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.954
H-Index - 188
eISSN - 1462-2920
pISSN - 1462-2912
DOI - 10.1111/1462-2920.13397
Subject(s) - biology , histidine kinase , regulator , response regulator , component (thermodynamics) , signal transduction , kinase , signalling , eukaryotic cell , microbiology and biotechnology , computational biology , genetics , bacterial protein , cell , histidine , gene , amino acid , physics , thermodynamics
Summary Two‐component system (TCS) signaling circuits regulate numerous cellular processes in response to environmental cues in both prokaryotic and eukaryotic cells. These signaling circuits are all based on phosphoryl‐group transfers between histidine and aspartate containing modules of sensor kinase and response regulator proteins. Curiously, the architecture and organization of prokaryotic and eukaryotic two‐component systems reveal notable variations, raising the question of whether the input‐response specificity that governs the majority of prokaryotic TCSs also governs the eukaryotic ones. In this review, we contrast the TCS architecture and signaling circuits of prokaryotes and eukaryotes, and discuss their possible consequences on signaling specificity.