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Nebivolol protects against cyclophosphamide‐induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis
Author(s) -
Wanas Hanaa,
ElShabrawy Mohamed,
Mishriki Amal,
Attia Hisham,
Emam Mohamed,
Aboulhoda Basma Emad
Publication year - 2021
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13481
Subject(s) - oxidative stress , nephrotoxicity , pharmacology , chemistry , nebivolol , reactive oxygen species , lipid peroxidation , inflammation , apoptosis , antioxidant , kidney , intraperitoneal injection , endocrinology , medicine , biochemistry , blood pressure
The usefulness of cyclophosphamide (CP) in the treatment of multiple human malignancies and immunological diseases is hindered by the danger of developing nephrotoxicity. The toxic metabolites of CP are suggested to be responsible for oxidative stress resulted from the production of reactive oxygen species (ROS) and stimulation of lipid peroxidation. Nebivolol (NEB) is a third‐generation selective B 1 adrenoceptor antagonist, but it has also various pharmacological properties such as anti‐inflammation, anti‐apoptotic, and antioxidant activities. Thus, the present study aims to explore the potential protective effect of NEB against CP‐induced nephrotoxicity. A cumulative dose of CP (75 mg/kg) was administered to albino rats by intraperitoneal injection. The protective effect of NEB was investigated by co‐administration of NEB (10 mg/kg orally daily). Administration of NEB with CP significantly improved renal functions and reduced the oxidative renal changes induced by CP injection. Co‐administration of NEB ameliorated apoptosis and inflammatory markers that were markedly exaggerated by CP. Our results indicated that NEB could be used as a protective agent against CP‐induced nephrotoxicity.