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IL‐33 promotes the progression of vascular restenosis after carotid artery balloon injury by promoting carotid artery intimal hyperplasia and inflammatory response
Author(s) -
Zeng Qingfu,
Xu Yingqi,
Zhang Wenwen,
Lv Fanzhen,
Zhou Weimin
Publication year - 2021
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13380
Subject(s) - restenosis , intimal hyperplasia , medicine , carotid arteries , cardiology , balloon , artery , hyperplasia , stent , smooth muscle
Interleukin (IL)‐33 is associated with vascular restenosis after carotid artery balloon injury. This work aims to investigate the involvement of IL‐33 in carotid artery balloon injury. We first constructed carotid artery balloon injury model in male Wistar rats. Then, we found that IL‐33 was highly expressed in the rats with carotid artery balloon injury 3, 14 and 21 days after surgery. Furthermore, IL‐33 treatment promoted inflammatory response and carotid artery intimal hyperplasia in the rats with carotid artery balloon injury, which was effectively improved by anti‐IL‐33 treatment. In addition, IL‐33 treatment enhanced proliferation, migration, inflammatory response and tube formation of human umbilical vein endothelial cells in a concentration‐dependent way. In summary, our study demonstrates that IL‐33 treatment promotes the progression of vascular restenosis after carotid artery balloon injury by enhancing carotid artery intimal hyperplasia and inflammatory response. Thus, our findings suggest that IL‐33 maybe a valuable target for carotid artery balloon injury therapies.