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Cerebral palsy: Aetiology, pathophysiology and therapeutic interventions
Author(s) -
Upadhyay Jyoti,
Tiwari Nidhi,
Ansari Mohd Nazam
Publication year - 2020
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13379
Subject(s) - etiology , cerebral palsy , pathophysiology , medicine , pediatrics , intensive care medicine , brain damage , neuroscience , physical medicine and rehabilitation , psychology , psychiatry , pathology
Cerebral palsy (CP) is the most common non‐progressive neurodevelopmental disorder in which the impairment of motor and posture functions occurs. This condition may be present in many different clinical spectra. Various aetiological and risk factors play a crucial role in the causation of CP. In various cases, the causes of CP may not be apparent. Interruption in the supply of oxygen to the fetus or brain asphyxia was considered to be the main causative factor explaining CP. Antenatal, perinatal, and postnatal factors could be involved in the origin of CP. Understanding its pathophysiology is also crucial for developing preventive and protective strategies. A major advancement in the brain stimulation techniques has emerged as a promising status in diagnostic and interventional approaches. This review provides a brief explanation about the various aetiological factors, pathophysiology, and recent therapeutic approaches in the treatment of cerebral palsy.