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A glimpse at growth hormone–releasing hormone cosmos
Author(s) -
Barabutis Nektarios
Publication year - 2020
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13324
Subject(s) - hormone , growth hormone–releasing hormone , medicine , endocrinology , growth hormone , vascular endothelial growth factor , peptide hormone , anterior pituitary , biology , vegf receptors
Growth hormone–releasing hormone is a hypothalamic neuropeptide, which regulates the secretion of growth hormone by the anterior pituitary gland. Recent evidence suggest that it exerts growth factor activities in a diverse variety of in vivo and in vitro experimental malignancies, which are counteracted by growth hormone–releasing hormone antagonists. Those peptides support lung endothelial barrier integrity by suppressing major inflammatory pathways and by inducing the endothelial defender P53. The present effort provides information regarding the effects of growth hormone–releasing hormone in the regulation of P53 and the unfolded protein response. Furthermore, it suggests the possible application of growth hormone–releasing hormone antagonists towards the management of acute lung injury, including the lethal acute respiratory distress syndrome.