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Down‐regulation of FOXR2 inhibits hypoxia‐driven ROS‐induced migration and invasion of thyroid cancer cells via regulation of the hedgehog pathway
Author(s) -
Liao ChongWu,
Zheng Chen,
Wang Le
Publication year - 2020
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13286
Subject(s) - hedgehog , hedgehog signaling pathway , reactive oxygen species , microbiology and biotechnology , biology , thyroid cancer , hypoxia (environmental) , cancer research , malignant transformation , cell migration , cancer cell , cell growth , chemistry , cell , signal transduction , thyroid , cancer , endocrinology , biochemistry , genetics , oxygen , organic chemistry
Forkhead box R2 (FOXR2), a new member of the FOX family, is involved in a wide range of biological processes such as embryogenesis, differentiation, transformation and metabolic homeostasis. Recently, FOXR2 has been reported to be aberrantly expressed in a variety of cancers and correlated with cancer development. However, the specific role of FOXR2 in thyroid cancer (TC) remains unclear. In this study, we showed that FOXR2 was highly expressed in TC tissues and cell lines. Moreover, down‐regulation of FOXR2 inhibited hypoxia‐induced reactive oxygen species (ROS) production and migration/invasion of TC cells. We also found that the hedgehog pathway was responsible for the partial mechanisms underlying the inhibitory effect. Taken together, these findings indicated that down‐regulation of FOXR2 inhibits hypoxia‐driven ROS‐induced migration and invasion of TC cells via regulation of the hedgehog pathway. Thus, FOXR2 may hold great potential for TC treatment.