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Short‐ and long‐term effects of maternal dyslipidaemia on blood pressure and baroreflex sensitivity in male rat offspring
Author(s) -
de Araújo Emmanuel Veríssimo,
Carneiro dos Santos Lucas Alves,
Speretta Guilherme Fleury Fina,
Ferreira Georgianna de Araújo Henriques,
de Luna Freire Micaelle Oliveira,
de Santana David Filipe,
CarvalhoGalvão Alynne,
Cruz Josiane Campos,
Costa-Silva João Henrique da,
Braga Valdir,
Brito Alves José Luiz
Publication year - 2020
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13174
Subject(s) - baroreflex , offspring , blood pressure , medicine , endocrinology , pregnancy , lactation , heart rate , biology , genetics
Maternal dyslipidaemia is a predisposing factor for arterial hypertension in male rat offspring at adulthood. This study was designed to investigate the short‐ and long‐term effects of maternal dyslipidaemia on blood pressure ( BP ) and baroreflex control in male rat offspring. Animals were obtained from mothers who received a dyslipidaemic ( DLP , n = 7) or control ( CTL , n = 7) diet during pregnancy and lactation. At 30 and 90 days of age, arterial pressure ( AP ), heart rate ( HR ) and baroreflex function were evaluated. In addition, spectral analysis of the systolic AP , diastolic AP , mean AP , HR , and spontaneous baroreflex were assessed. Data were expressed as mean ± SEM and Student's t ‐test was used for comparison among groups, with statistical significance considered to be P < .05. At 30 days of age, male offspring had similar BP , HR and preserved baroreflex sensitivity. In addition, low frequency ( LF ) oscillation, high frequency ( HF ) oscillation and LF / HF ratio of AP and HR were similar in juvenile rats. At 90 days of age, male offspring from dyslipidaemic dams had augmented BP ( P < .05) when compared to CTL group. Adult male rats from dyslipidaemic dams had a reduction in baroreflex control ( P < .05) in comparison to CTL rats. The present study indicates that offspring from dams fed on a dyslipidaemic diet during pregnancy and lactation do not show alteration in blood pressure and baroreflex control in early life, but display a decline in baroreflex control and hypertension in adulthood.