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Elevated plasma Pim‐1 and its clinical significance in patients with pulmonary arterial hypertension
Author(s) -
Zhu Tengteng,
Luo Jun,
Wang Yi,
Xiong Xianliang,
Sheng Bin,
Yang Xiaojie,
Ndongala Nsusu A. Mpembe Tresor,
Li Jiang
Publication year - 2019
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13102
Subject(s) - medicine , pulmonary artery , pulmonary hypertension , cardiology , vascular resistance , biomarker , blood pressure , chemistry , biochemistry
This study was aimed to determine plasma Pim‐1 levels in patients with pulmonary arterial hypertension ( PAH ) and to estimate the clinical value of Pim‐1 as a biomarker of PAH . This was a single‐centre retrospective study in 111 patients with congenital heart disease ( CHD ) and idiopathic PAH ( IPAH ). Those CHD patients were divided into two groups: PAH associated with CHD ( PAH ‐ CHD ) and CHD without PAH ( nPAH ‐ CHD ). Plasma Pim‐1 levels were measured by enzyme‐linked immunosorbent assay. (a) Plasma Pim‐1 levels were significantly increased in patients with PAH ‐ CHD and IPAH compared with the healthy control group (27.81 ± 11.34 ng/mL vs 13.02 ± 5.30 ng/mL; 32.81 ± 12.28 ng/mL vs 13.02 ± 5.30 ng/mL, P < 0.05) and nPAH ‐ CHD (27.81 ± 11.34 ng/mL vs 17.33 ± 7.99 ng/mL; 32.81 ± 12.28 ng/mL vs 17.33 ± 7.99 ng/mL, P < 0.05). Pim‐1 levels were substantially increased in patients with severe PAH ‐ CHD compared with mild‐to‐moderate PAH ‐ CHD (19.12 ± 6.70 ng/mL vs 8.54 ± 3.71 ng/mL, P < 0.05). (b) Pim‐1 levels were correlated positively with the mean pulmonary artery pressure ( mPAP ) and pulmonary vascular resistance ( PVR ) ( r = 0.582, 0.516; P < 0.001, respectively), while negatively with tricuspid annular plane systolic excursion ( TAPSE ), tricuspid annular plane systolic velocity (S’) and right ventricular fractional area changes ( RVFAC ) ( r = −0.375, −0.354, −0.507; P < 0.05, respectively). (c) PAH ‐ CHD and severe PAH ‐ CHD was identified by plasma Pim‐1 with a cutoff value of 16.8 ng/mL ( P < 0.001) with a sensitivity of 87.3% and a specificity of 65%, and a cutoff value of 20.53 ng/mL ( P < 0.001) with a sensitivity of 87.3% and a specificity of 52%, respectively. Plasma Pim‐1 levels were significantly higher in patients with PAH ‐ CHD and IPAH . Plasma Pim‐1 may represent an effectively biomarker in patients with PAH.