Premium
Low KISS 1 expression predicts poor prognosis for patients with colorectal cancer: A meta‐analysis
Author(s) -
Wang XiaoQing,
Fang PeiFei,
Zhang Cheng,
Xu YaYun,
Song XianBing,
Liang Jun,
Xia QingRong
Publication year - 2019
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13093
Subject(s) - meta analysis , medicine , colorectal cancer , oncology , publication bias , metastasis , distant metastasis , cancer
KISS 1 and KISS 1R, a novel pair of metastasis suppressors, are likely to be associated with the prognosis of colorectal cancer ( CRC ). Here, a meta‐analysis was performed to study the role of KISS 1 and KISS 1R in CRC . Heterogeneity, stability and publication bias were all estimated. Six publications describing a total of 559 CRC patients were included in the present study. Low KISS 1 expression predicted 70% higher risk of poor prognosis for general patients ( HR , 1.71; 95% CI , 1.28–2.29) and 99% higher risk for East Asian patients ( HR , 1.99; 95% CI , 1.46–2.72). Limited evidence indicated that decreased KISS 1R expression might predict poor outcome ( HR , 2.96; 95% CI , 1.51–5.82). Neither heterogeneity nor publication bias was identified. The current analyses suggest that low KISS 1 expression predicts poor overall survival among East Asian patients with CRC . Evidence on other races and KISS 1R are still insufficient, and additional studies are required to clarify the risk of CRC associated with KISS 1R by race.