Research Library

Premium Evaluation of the potentiating effects of antidepressants on the contractile response to noradrenaline in guinea pig urethra smooth muscles
Author(s)
Obara Keisuke,
Imanaka Satoko,
Fukuhara Hiroka,
Yamaki Fumiko,
Matsuo Kazuhiro,
Yoshio Takashi,
Tanaka Yoshio
Publication year2019
Publication title
clinical and experimental pharmacology and physiology
Resource typeJournals
PublisherWiley-Blackwell
Summary We investigated the potential augmenting effects of 19 clinically available antidepressants on noradrenaline ( NA )‐induced contractions in guinea pig urethra smooth muscle ( USM ). Concentration‐response curves for NA ‐induced contractions in guinea pig USM strips were obtained in the absence or presence of selected antidepressants. Desipramine, an active metabolite of imipramine, produced a contraction and potentiated NA ‐induced contraction at the distal urethra without affecting the proximal urethra. Further, nortriptyline and amoxapine, tricyclic antidepressants, produced a contraction and potentiated NA ‐induced contraction at the distal urethra. NA ‐induced contraction was unaffected or reduced by imipramine, clomipramine, trimipramine, and amitriptyline at the proximal and distal urethra. Maprotiline, a tetracyclic antidepressant, potentiated NA ‐induced contraction at the distal urethra. NA ‐induced contraction was unaffected by mianserin at the proximal and distal urethra. Paroxetine, a selective serotonin reuptake inhibitor ( SSRI ), potentiated NA ‐induced contraction at the distal urethra, while NA ‐induced contraction was unaffected by fluvoxamine, sertraline, and escitalopram at the proximal and distal urethra. Milnacipran, a serotonin‐noradrenaline reuptake inhibitor ( SNRI ), potentiated NA ‐induced contraction at the proximal and distal urethra, whereas duloxetine potentiated it at the distal urethra. Mirtazapine slightly inhibited NA ‐induced contraction at the distal urethra. Aripiprazole and sulpiride did not affect NA ‐induced contractions at the proximal nor distal urethra. Trazodone inhibited NA ‐induced contraction at both urethras. Desipramine, nortriptyline, amoxapine, maprotiline, paroxetine, milnacipran, and duloxetine likely induce urinary disturbance by increasing urethral resistance and augmenting NA ‐induced contraction, which should be carefully considered when delivering guidance for drug administration to patients.
Subject(s)antidepressant , chemistry , contraction (grammar) , desipramine , endocrinology , hippocampus , maprotiline , medicine , pharmacology , urethra , urology
Language(s)English
SCImago Journal Rank0.752
H-Index103
eISSN1440-1681
pISSN0305-1870
DOI10.1111/1440-1681.13072

Seeing content that should not be on Zendy? Contact us.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here